Bosutinib is selective for Src over non-Src family kinases with an IC50 of nM, and potently inhibits Src-dependent cell proliferation with an IC50 of 100 nM.  Bosutinib significantly inhibits the proliferation of Bcr-Abl-positive leukemia cell lines KU812, K562, and MEG-01 but not Molt-4, HL-60, Ramos, and other leukemia cell lines, with IC50 of 5 nM, 20 nM and 20 nM, respectively, more potently than that of STI-571. Similar to STI-571, Bosutinib displays antiproliferative activity against the Abl-MLV-transformed fibroblasts with IC50 of 90 nM. Bosutinib ablates tyrosine phosphorylation of Bcr-Abl and STAT5 in CML cells and of v-Abl expressed in fibroblasts at the concentration of ~50 nM, 10-25 nM and 200 nM, respectively, leading to the Bcr-Abl downstream signaling inhibition of Lyn/Hck phosphorylation.  Although unable to inhibit the proliferation and survival of breast cancer cells, Bosutinib significantly decreases the motility and invasion of breast cancer cells with IC50 of ~250 nM, involved with an increase in cell-to-cell adhesion and membrane localization of β-catenin. 
The oldest amber recovered dates to the Upper Carboniferous period ( 320 million years ago ).   Its chemical composition makes it difficult to match the amber to its producers – it is most similar to the resins produced by flowering plants ; however, there are no flowering plant fossils until the Cretaceous, and they were not common until the Upper Cretaceous . Amber becomes abundant long after the Carboniferous, in the Early Cretaceous , 150 million years ago ,  when it is found in association with insects . The oldest amber with arthropod inclusions comes from the Levant, from Lebanon and Jordan. This amber, roughly 125–135 million years old, is considered of high scientific value, providing evidence of some of the oldest sampled ecosystems .