I am a two-time survior of the devasting bacterial infection known as C-Diff. Since I am an otherwise completely healthy female (was 35 and 44 when I contracted), it was unexpected that the disease would nearly kill me – twice. I have taken liquid vancomycin for nearly nine months now, but it has not cured me. I had the good fortune of learning from my infectious disease doctor and obtaining an opinion from an expert at Johns Hopkins Hospital about my case, and both concurred that I should consider opting for a fecal transplant as vancomycin hasn’t cured me. Although the procedure is usually done at the hospital and is 90-95% effective (so I am told), my husband and I are doing the home-style version. A fecal transplant is done by taking the stole of a healthy, close family member, mixing it with saline solution in a blender, putting it through a seive, and “inplanting” the donor’s good bacteria via an enema bottle into your intestines via your rectum. Although it was quite disgusting the first day, it gets easier. I noticed a dramatic improvement within 12 hours. Anyone having gone through a severe case of C-Diff knows that the fecal transplant procedure is not nearly as tramatic and painful as living with this infection. Quite frankly, the fecal transplant may save my life.
Between-group comparisons for pooled placebo-controlled trials in adults revealed no statistically significant differences between risperidone and placebo in mean changes from baseline in ECG parameters, including QT, QTc, and PR intervals, and heart rate. When all RISPERDAL® doses were pooled from randomized controlled trials in several indications, there was a mean increase in heart rate of 1 beat per minute compared to no change for placebo patients. In short-term schizophrenia trials, higher doses of risperidone (8-16 mg/day) were associated with a higher mean increase in heart rate compared to placebo (4-6 beats per minute). In pooled placebo-controlled acute mania trials in adults, there were small decreases in mean heart rate, similar among all treatment groups.