Hi Ben. Thanks for all the amazing info week after week. I love your podcasts and articles. I would love your opinion on using BPC 157 injections as you describe in the article for a very persistent case of posterior tibial tendonitis. Even with quite a bit of rest, using a walking boot, eating anti inflammatory, and working on correcting running form/strengthening, this tendonitis has plagued me for three months now. I am an avid distance runner and need this to heal? Please let me know if you think this could be effective, and if you would recommend any changes to your protocol in the article. Also, how much would my results be diminished if I used the bps orally not subcutaneously? Lastly, where should I inject the bpc if I go that route? I have pain mostly right around the malleolus, but often into my arch and above the malleolus along the tendon. thanks again
There are possible estrogenic side effects of Nandrolone despite it not being a very estrogenic hormone, at least not directly. Nandrolone does aromatize slightly. Aromatization refers to the conversion of testosterone to estrogen . This takes place when the testosterone hormone interacts with the aromatase enzyme. When the conversion takes place this can cause estrogen levels to go up, which can promote gynecomastia and water retention. High blood pressure can also become an issue if water retention becomes severe. Along with the low level of aromatase activity Nandrolone is also a progestin and has a strong binding affinity for the progesterone receptor. This may stimulate the mammary tissue and enhance the risk of gynecomastia in sensitive individuals.
Combating the estrogenic side effects of Nandrolone can be achieved by the use of anti-estrogen medications, specifically Aromatase Inhibitors (AI’s) such as Anastrozole ( Arimidex ). Selective Estrogen Receptor Modulators (SERM’s) are also sometimes used, such as Tamoxifen ( Nolvadex ). However, AI’s are the proper choice as they will directly reduce serum estrogen levels and SERM’s will not. An AI should be enough to reduce and avoid gynecomastia unless the individual already has existing gynecomastia that could potentially be exasperated.
Important Note: It’s often been said that Nandrolone based gynecomastia is based on increases in prolactin. It is true that 19-nor steroids can increase prolactin, which can also negatively affect libido and erection function. Some men may need to use a dopamine agonist to combat this. However, it is not prolactin that causes 19-nor based gynecomastia but rather the imbalance between estrogen and progesterone. If you merely combat prolactin you may find yourself with the very gynecomastia you tried to avoid.