However, I want to make a small quibble with one bit in this blog. You say that ovulation “occurs precisely at the start of week three of the cycle” and this is most certainly NOT the case for all women. The perfect 28-day cycle is a myth. I don’t know whether every woman’s cycle “should” be 28 days exactly with ovulation occurring precisely at day 14. Maybe that’s how it is for everyone when hormones are in perfect balance. But that isn’t the reality. I ovulate around day 20-23 (and have ~35 day cycles) and some women ovulate around day 10-12.
ERα/ERβ are in inactive state trapped in multimolecular chaperone complexes organized around the heat shock protein 90 (HSP90), containing p23 protein, and immunophilin, and located in majority in cytoplasm and partially in nucleus. In the E2 classical pathway or estrogen classical pathway, estradiol enters the cytoplasm , where it interacts with ERs. Once bound E2, ERs dissociate from the molecular chaperone complexes and become competent to dimerize, migrate to nucleus, and to bind to specific DNA sequences ( estrogen response element , ERE), allowing for gene transcription which can take place over hours and days.