Low testosterone young

A 31-year-old man presenting with an 18-month history of sexual dysfunction resulting from severe adult-onset IHH (LH U/L, FSH U/L, T nmol/L). Initial therapy with 50 mg of clomiphene citrate (CC) three times a day for 7 days, with overnight LH pulse profiling and 9 am T levels evaluated at baseline and on completion. A 2-month washout period, followed by low-dose maintenance therapy (25-50 mg/d) for 4 months.
MAIN OUTCOME MEASURE(S):Baseline and stimulated T levels and LH pulsatility; effect on sexual function.
RESULT(S):Clomiphene therapy resulted in complete normalization of pulsatile gonadotropin secretion, serum T level, and sexual function. CONCLUSION(S):Isolated hypogonadotropic hypogonadism may result from an acquired defect of enhanced hypothalamic sensitivity to E-mediated negative feedback. Whereas direct T replacement therapy can further suppress endogenous gonadotropin secretion, treating IHH men with gonadotropins can stimulate endogenous T secretion and enhance fertility potential. On theoretical grounds, reversal of gonadotropin deficiency with CC might be expected to have a similar biological effect.

For both men and women, an alternative to testosterone replacement is low-dose clomifene treatment, which can stimulate the body to naturally increase hormone levels while avoiding infertility and other side effects that can result from direct hormone replacement therapy. [17] This therapy has only been shown helpful for men with secondary hypogonadism. Recent studies have shown it can be safe and effective monotherapy for up to 2 years in patients with intact testicular function and impaired function of the HPTA( http:///ijir/journal/v15/n3/full/ ). Clomifene blocks estrogen from binding to some estrogen receptors in the hypothalamus, thereby causing an increased release gNRH and subsequently LH from the pituitary. Clomifene is a Selective Estrogen Reuptake Modulator (SERM). Generally clomifene does not have adverse effects at the doses used for this purpose. Clomifene at much higher doses is used to induce ovulation and has significant adverse effects in such a setting.

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There are several relatively simple lifestyle changes a woman can make that might elevate T levels. Most obviously, if a woman believes her birth control pills are causing a problem and she feels she can adjust to a different type of birth control, she might stop using them (if indeed she's using them exclusively to prevent conception). She might also reevaluate her need for any of the various medications I mentioned, and perhaps seek alternatives that might not affect testosterone levels. For instance, there's some evidence that the antidepressant wellbutrin actually increases libido, but whether it helps the sex mojo through raising T levels or by some other mechanism isn't well understood.

Low testosterone young

low testosterone young

There are several relatively simple lifestyle changes a woman can make that might elevate T levels. Most obviously, if a woman believes her birth control pills are causing a problem and she feels she can adjust to a different type of birth control, she might stop using them (if indeed she's using them exclusively to prevent conception). She might also reevaluate her need for any of the various medications I mentioned, and perhaps seek alternatives that might not affect testosterone levels. For instance, there's some evidence that the antidepressant wellbutrin actually increases libido, but whether it helps the sex mojo through raising T levels or by some other mechanism isn't well understood.

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