Occasionally, testosterone injections are preferred over creams or gels. There are three reasons for this. Firstly injections are prepared from formulations that are much cheaper than creams. Secondly, injecting testosterone is a safer method because creams can potentially cause allergies to the person who comes in contact with the substance. Besides, the injections need to be administered less often than creams which mean you will have to go through the embarrassment and misery less frequently. On the flip side, applying creams will reveal your condition to your partner which is something most people don’t want.
Testosterone, like many anabolic steroids, was classified as a controlled substance in 1991. Testosterone is administered parenterally in normal and delayed-release (depot) forms. In September 1995, the FDA approved testosterone transdermal patches (Androderm), and many transdermal forms and brands are now available including implants, gels, and topical solutions. A testosterone buccal system, Striant, was FDA-approved in July 2003; Striant is a mucoadhesive product that adheres to the buccal mucosa and provides a controlled and sustained release of testosterone. In May 2014, the FDA approved an intranasal gel formulation of testosterone (Natesto). A transdermal patch (Intrinsa) for hormone replacement in women is under investigation; the daily dosages used in women are much lower than for products used in males. The FDA refused approval for Intrinsa in 2004 stating that more data regarding safety, especially in relation to cardiovascular and breast health, were required.
Though this may be normal, some men feel the effects more strongly than others. Low testosterone levels may contribute to depression, decreased bone density, increased body fat, insomnia, and diminished sexual desire . For these reasons, some doctors prescribe T to their patients with only age-related hormone decline. While prescription testosterone is an FDA-approved therapy, the agency only sanctions it for men who have low T levels due to disorders causing hypogonadism, where the body doesn’t produce enough of the hormone. The benefits and safety of using T to treat age-related low levels have not been established, says the FDA.